التفاصيل البيبلوغرافية
| العنوان: |
Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus. |
| المؤلفون: |
Éva Korpos, Zsuzsanna Buzás, Ibolya Kiss, Zoltán Zomborszky, Péter Papp, Ferenc Deák |
| المصدر: |
Molecular Genetics & Genomics; Mar2007, Vol. 277 Issue 3, p237-248, 12p |
| مصطلحات موضوعية: |
ANTLERS, RED deer, BONE growth, CELL differentiation, GENE expression, DEVELOPMENTAL biology |
| مستخلص: |
Abstract??Understanding the molecular mechanisms underlying bone development is a fundamental and fascinating problem in developmental biology, with significant medical implications. Here, we have identified the expression patterns for 36 genes that were characteristic or dominant in the consecutive cell differentiation zones (mesenchyme, precartilage, cartilage) of the tip section of the developing velvet antler of red deerCervus elaphus. Two major functional groups of these genes clearly outlined: six genes linked to high metabolic demand and other five to tumor biology. Our study demonstrates the advantages of the antler as a source of mesenchymal markers, for distinguishing precartilage and cartilage by different gene expression patterns and for identifying genes involved in the robust bone development, a striking feature of the growing antler. Putative roles for ?antler? genes that encode ?-tropomyosine (tpm1), transgelin (tagln), annexin 2 (anxa2), phosphatidylethanolamine-binding protein (pebp) and apolipoprotein D (apoD) in intense but still controlled tissue proliferation are discussed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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