التفاصيل البيبلوغرافية
| العنوان: |
Differences in Baseline Nasal Secretions Between Chronic Fatigue Syndrome (CFS) and Control Subjects. |
| المؤلفون: |
Naranch, K., Repka-Ramirez, S. M., Park, Y.-J., Velarde, A., Finnegan, R., Murray, J., Pheiffer, A., Hwang, E., Clauw, D., Baraniuk, J. N. |
| المصدر: |
Journal of Chronic Fatigue Syndrome; 2002, Vol. 10 Issue 1, p3-15, 13p, 2 Charts |
| مصطلحات موضوعية: |
ALLERGIC rhinitis, RHINITIS, FIBROMYALGIA, SINUSITIS, CHRONIC diseases, CHRONIC fatigue syndrome, PATIENTS |
| مستخلص: |
Objective: To assess potential mechanism(s) for the rhinitis found in Chronic Fatigue Syndrome (CFS) subjects. Methods: The concentration of mucus constituents were measured in basal nasal lavage fluids of 103 CFS and 92 non-CFS control subjects. Subjects were further characterized by their Rhinitis Score and allergy skin test results into nonallergic and allergic rhinitis, atopic, and negative subgroups to determine if differences were related to atopy. Other questionnaires of irritant sensitivity and medicine use were completed. Results: Mucin polysaccaride (p = 0.043, ANOVA), free hemoglobin (p = 0.0044), mucin/total protein (p = 0.039) and hemoglobin/total protein (p = 0.043) were much higher in CFS than controls. CFS subjects with positive Rhinitis Scores (p = 0.023) or skin tests (p = 0.047) had higher mucin levels than those with negative values. For all subjects, inceased mucin was correlated with total protein (Pearson's r2 = 0.188) and inhaled corticosteroid use (r2 = 0.082) and elevated Tobacco Scores (r2 = 0.061). Other correlations with demographic, medication, or questionnaire responses gave r2 < 0.05. Conclusions: CFS subjects have a higher level of complaints in many systems including the nose. They appear to have an irritant (nonallergic) rhinitis with increased mucin production and mucosal friability (epistaxis of hemoglobin). Nasal and systemic drugs do not explain these significant baseline changes. [ABSTRACT FROM PUBLISHER] |
|
Copyright of Journal of Chronic Fatigue Syndrome is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
PDF full text from Publisher