التفاصيل البيبلوغرافية
| العنوان: |
Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers. |
| المؤلفون: |
Skliris, G. P., Hub, F., Gheorghiu, I., Mutawe, M. M., Penner, C., Watson, P. H., Murphy, L. C., Leygue, E., Myal, Y. |
| المصدر: |
Histopathology; Feb2008, Vol. 52 Issue 3, p355-369, 15p, 2 Color Photographs, 1 Black and White Photograph, 5 Charts, 1 Graph |
| مصطلحات موضوعية: |
BREAST cancer, MUCINS, CANCER prognosis, PROTEIN microarrays, CANCER invasiveness, PROGNOSIS |
| مستخلص: |
Aims: Small breast epithelial mucin (SBEM) is a recently described gene product that shows promise as a new breast biomarker. The aim was to investigate for the first time SBEM protein expression in a large cohort ( n = 300) of invasive breast cancers, its relationship to established clinical variables and its association with clinical outcome. Methods and results: Immunohistochemical analysis was performed on tissue microarrays consisting of 149 oestrogen receptor (ER) α− and 151 ERα+ breast cancers. Overall, 18% of tumours were SBEM+ ( n = 53/300). However, SBEM protein was more frequently observed in ER− (22%) than in ER+ cancers (13%; P = 0.049). A significant association with psoriasin/S100A7 expression ( P ≤ 0.0001) was observed in the entire cohort. SBEM was also positively associated with HER-2 ( P = 0.046) in ER− cancers, and increased levels of SBEM were strongly associated with higher tumour grade ( P = 0.0015). Furthermore, SBEM expression showed a trend towards an association with reduced overall survival and relapse-free survival in the ER+ cohort ( P = 0.063 and P = 0.072, respectively). Conclusions: Our results suggest that SBEM may identify a unique subset of breast cancers with poor prognosis and may have future implications for therapeutic management of this disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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