التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors. |
| المؤلفون: |
Hong-gang Hu, Ming-juan Wang, Qing-jie Zhao, Hong-li Liao, Ling-zhi Cai, Yan Song, Jun Zhang, Shi-chong Yu, Wan-sheng Chen, Chao-mei Liu, Qiu-ye Wu |
| المصدر: |
Chemistry of Natural Compounds; Nov2007, Vol. 43 Issue 6, p663-666, 4p, 1 Chart |
| مصطلحات موضوعية: |
PROTEIN-tyrosine phosphatase, GLUCOSIDES, PHOSPHATASES, TYPE 2 diabetes, OBESITY |
| مستخلص: |
Protein tyrosine phosphatase 1B (PTP1B) has received much attention due to its pivotal role in type 2 diabetes and obesity as a negative regulator of the insulin signaling pathway. Mangiferin, a xanthone glucoside, has been reported to possess significant antidiabetic activity. In the present study, a series of mangiferin derivatives was synthesized and evaluated for their PTP1B inhibitory activity. Some of the screened compounds displayed good PTP1B inhibitory activity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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