التفاصيل البيبلوغرافية
| العنوان: |
Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase. |
| المؤلفون: |
Koppelman, Bruce, Webb, Heather K., Medicherla, Satyanarayana, Almirez, Ramona, Feng, Ying, Chavez, Jose Carlos, Mao, Cheng Ping, Nguyen, Aaron, Liu, Yu-Wang, Kapoun, Ann M., Muiru, Gladys, Huang, Yuanying Anne, Dugar, Sundeep, Mavunkel, Babu J., Lim, Don W., Chakravarty, Sarvajit, Luedtke, Gregory, Protter, Andrew A., Higgins, Linda S. |
| المصدر: |
Pharmacology; 2007, Vol. 81 Issue 3, p204-220, 17p, 1 Chart, 9 Graphs |
| مصطلحات موضوعية: |
SEPSIS, ANTIASTHMATIC agents, BRONCHIAL diseases, OBSTRUCTIVE lung diseases, RESPIRATORY allergy |
| مستخلص: |
The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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