التفاصيل البيبلوغرافية
| العنوان: |
Genetic polymorphisms of adiponectin and tumor necrosis factor-alpha and nonalcoholic fatty liver disease in Chinese people. |
| المؤلفون: |
Wai-Sun Wong, Vincent, Lai-Hung Wong, Grace, Woon-Choi Tsang, Steven, Yui Hui, Alex, Wing-Hong Chan, Anthony, Cheung-Lung Choi, Paul, Wing-Yee So, Mei-Ling Tse, Ada, Ka-Leung Chan, Francis, Jao-Yiu Sung, Joseph, Lik-Yuen Chan, Henry |
| المصدر: |
Journal of Gastroenterology & Hepatology; Jun2008, Vol. 23 Issue 6, p914-921, 8p, 5 Charts |
| مصطلحات موضوعية: |
FATTY liver, GENETIC polymorphisms, TUMOR necrosis factors, CYTOKINES, GLYCOPROTEINS, FATTY degeneration, LIVER diseases, CHINESE people, DISEASES |
| مستخلص: |
Background and Aim: Hypoadiponectinemia and high tumor necrosis factor-alpha (TNF-α) levels are associated with the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the genetic polymorphisms of adiponectin and TNF-α in Chinese NAFLD patients and their association with disease severity. Methods: Seventy-nine patients with histology-proven NAFLD (61 with simple steatosis and 18 with stage 2–4 fibrosis) and 40 controls were tested for the nucleotide polymorphisms at adiponectin −11 391, −11 377, +45, and +276 and TNF-α promoters −863, −308, and −238. Results: There was no significant deviation in the adiponectin and TNF-α gene polymorphisms between NAFLD patients and controls, or between patients with simple steatosis and those with stage 2–4 fibrosis. NAFLD patients with −11377G and +45G at the adiponectin gene were more likely to have hypertriglyceridemia. On multivariate analysis, older age, higher body mass index, and higher fasting glucose were independent factors associated with stage 2–4 fibrosis in NAFLD patients. Conclusions: Adiponectin and TNF-α gene polymorphisms were not shown to be associated with NAFLD or significant fibrosis in Chinese people. The adiponectin −11377G and +45G alleles were associated with hypertriglyceridemia in NAFLD patients. Since the current study is not adequately powered to detect smaller differences in allele frequencies, larger-sized studies in different ethnic groups are required. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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