التفاصيل البيبلوغرافية
| العنوان: |
Aetiology and outcome of acute and chronic renal failure in infants. |
| المؤلفون: |
Mirja Wedekin, Jochen HH Ehrich, Gisela Offner, Lars Pape |
| المصدر: |
Nephrology Dialysis Transplantation; May2008, Vol. 23 Issue 5, p1575-1575, 1p |
| مصطلحات موضوعية: |
ETIOLOGY of diseases, PEDIATRIC therapy, KIDNEY diseases, CREATININE |
| مستخلص: |
Background. The aetiology and outcome of acute (ARF) and chronic renal failure (CRF) in infants were analysed in a retrospective study. Methods. Between January 1997 and April 2004 all children <1 year of age with a serum creatinine >100 μmol/l at Hannover Medical School were followed up for up to 6 years. One hundred and nineteen children with a serum creatinine >100 μmol/l were identified, 70 infants suffering from ARF and 49 from chronic kidney disease (CKD), stages 3–5. Results. Renal failure was caused in 49/119 (41%) by congenital and in 70/119 (59%) by acquired diseases. The aetiology of ARF (n = 70) included cardiac (27%), prematurity (27%), septic (10%), hepatic (9%), renal (9%) and other (18%) causes. Twelve infants needed transient dialysis treatment. Renal function recovered in all surviving children. The mortality rate was 37%. Causes of death were unrelated to kidney function. Twenty-one of 49 infants with CKD were dialyzed with a median age of 65 days at the start of dialysis, and 23/49 children received a kidney transplant (RTx). The 5-year patient and graft survival for RTx-children of 95.5% was not different from older children. The 5-year patient survival rate of 26 children with CKD without RTx was 63%. The causes of death were parental refusal of therapy in neonates (n = 4) and life-threatening extra-renal comorbidity (n = 3). Conclusion. Renal replacement therapy offers good chances of survival in infants without life-threatening comorbidity. Patient survival of infants treated for CKD in the first year of life was comparable to that of older children. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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