التفاصيل البيبلوغرافية
العنوان: |
Inhibitory Effects of Baicalin on Ultraviolet B-Induced Photo-Damage in Keratinocyte Cell Line. |
المؤلفون: |
Wei Min, Xiang-Fei Lin, Xu Miao, Bao-Tao Wang, Zi-Liang Yang, Dan Luo |
المصدر: |
American Journal of Chinese Medicine; 2008, Vol. 36 Issue 4, p745-760, 16p, 1 Color Photograph, 2 Black and White Photographs, 2 Charts, 4 Graphs |
مصطلحات موضوعية: |
CHINESE medicine, QI gong, CLINICAL medicine, CARCINOGENESIS, CELL-mediated cytotoxicity |
مستخلص: |
Baicalin, one kind of Chinese herbal medicine with anti-inflammatory and anti-oxidant property, has been commonly used as a clinical medicine. However, little has been known about the effects of Baicalin on ultraviolet (UV) induced photo-aging and photo-carcinogenesis. The photoproduct is critical to the initial event of UV-induced photo-carcinogenesis. The purpose of the present study was to investigate whether Baicalin, in immortalized human keratinocyte HaCaT cells, could inhibit ultraviolet-B (UVB) induced skin damage and its possible underlying mechanisms, such as inhibiting UVB-induced cytotoxicity and apoptosis, cyclobutane pyrimidine dimers (CPDs), down-regulating the expression of regulatory proteins which are related to cell apoptosis and DNA damage/repair. Our study revealed that Baicalin treatment could inhibit the UVB-induced cytotoxicity, apoptosis and CPD level. It also decreased the mRNA expression of apoptosis-regulatory genes (p53-p21 and c-fos), the protein levels of p53, proliferating cell nuclear antigen (PCNA) and repair protein A (RPA), and the secretion of cytokines [interleukin(IL)-6 and tumor necrosis factor (TNF-α)]. These results suggested that Baicalin may have an inhibitory effect on the UVB-induced photo-damage by blocking the relevant cytokine secretion and expression of p53-p21, c-fos, PCNA and RPA genes. [ABSTRACT FROM AUTHOR] |
|
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |