التفاصيل البيبلوغرافية
| العنوان: |
Inhibitory Effects of Baicalin on Ultraviolet B-Induced Photo-Damage in Keratinocyte Cell Line. |
| المؤلفون: |
Wei Min, Xiang-Fei Lin, Xu Miao, Bao-Tao Wang, Zi-Liang Yang, Dan Luo |
| المصدر: |
American Journal of Chinese Medicine; 2008, Vol. 36 Issue 4, p745-760, 16p, 1 Color Photograph, 2 Black and White Photographs, 2 Charts, 4 Graphs |
| مصطلحات موضوعية: |
CHINESE medicine, QI gong, CLINICAL medicine, CARCINOGENESIS, CELL-mediated cytotoxicity |
| مستخلص: |
Baicalin, one kind of Chinese herbal medicine with anti-inflammatory and anti-oxidant property, has been commonly used as a clinical medicine. However, little has been known about the effects of Baicalin on ultraviolet (UV) induced photo-aging and photo-carcinogenesis. The photoproduct is critical to the initial event of UV-induced photo-carcinogenesis. The purpose of the present study was to investigate whether Baicalin, in immortalized human keratinocyte HaCaT cells, could inhibit ultraviolet-B (UVB) induced skin damage and its possible underlying mechanisms, such as inhibiting UVB-induced cytotoxicity and apoptosis, cyclobutane pyrimidine dimers (CPDs), down-regulating the expression of regulatory proteins which are related to cell apoptosis and DNA damage/repair. Our study revealed that Baicalin treatment could inhibit the UVB-induced cytotoxicity, apoptosis and CPD level. It also decreased the mRNA expression of apoptosis-regulatory genes (p53-p21 and c-fos), the protein levels of p53, proliferating cell nuclear antigen (PCNA) and repair protein A (RPA), and the secretion of cytokines [interleukin(IL)-6 and tumor necrosis factor (TNF-α)]. These results suggested that Baicalin may have an inhibitory effect on the UVB-induced photo-damage by blocking the relevant cytokine secretion and expression of p53-p21, c-fos, PCNA and RPA genes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
