التفاصيل البيبلوغرافية
| العنوان: |
HIV-1-infected patients from the French National Observatory experiencing virological failure while receiving enfuvirtide. |
| المؤلفون: |
Diane Descamps, Lambert Assoumou, Bernard Masquelier, Anne-Geneviève Marcelin, Souhila Saidi, Catherine Tamalet, Jacqueline Cottalorda, Jean-Christophe Plantier, Brigitte Montes, Jacques Izopet, Gilles Peytavin, Sabine Yerly, Véronique Schneider, Constance Delaugerre, Virginie Ferré, Annick Ruffault, Coralie Pallier, Laurence Morand-Joubert, Marie-Laure Chaix, Vincent Calvez |
| المصدر: |
Journal of Antimicrobial Chemotherapy (JAC); Sep2008, Vol. 62 Issue 3, p451-451, 1p |
| مصطلحات موضوعية: |
HIV-positive persons, PATIENTS, HIV infections, AIDS patients |
| مستخلص: |
: Objectives We studied gp41 mutations associated with failing enfuvirtide salvage therapy. : Methods This multicentre study involved patients with HIV-1 plasma viral load (pVL) > 5000 copies/mL after at least 3 months of uninterrupted enfuvirtide therapy and with plasma samples available at inclusion (T0), at initial enfuvirtide failure (T1) and at last follow-up visit during continued failing enfuvirtide therapy (T2). The HR-1 and HR-2 domains of the gp41 gene were sequenced at T0, T1 and T2. : Results Ninety-nine patients were enrolled. At baseline, the median pVL and CD4 cell count were 5.1 log copies/mL and 72 cells/mm3, respectively. Based on the ANRS Resistance Group algorithm, the proportion of patients harbouring viruses with enfuvirtide resistance mutations increased significantly between T0 and T1. In the HR-1 domain, the V38A/M, Q40H, N42T, N43D and L45M mutations wereselected (P < 0.02). In the HR-2 domain, no mutations were significantly selected during the follow-up. None of the mutations was associated with a CD4 cell count increment. : Conclusions Mutations selected during failing enfuvirtide salvage therapy are mainly located in the HR-1 domain of the gp41 gene, between codons 38 and 45. No mutations were associated with an increase in the CD4 cell count. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder