التفاصيل البيبلوغرافية
| العنوان: |
Effects of Acrylamide on the Nervous Tissue Antioxidant System and Sciatic Nerve Electrophysiology in the Rat. |
| المؤلفون: |
Tao Zeng, Ying-Biao Zhu, Su-Fang Yu, Qing-Shan Wang, Li-Ping Zhang, Xin Guo, Ke-Qin Xie |
| المصدر: |
Neurochemical Research; Nov2008, Vol. 33 Issue 11, p2310-2317, 8p |
| مصطلحات موضوعية: |
TISSUES, HISTOLOGY, ORGANS (Anatomy), AUTOLYSIS |
| مستخلص: |
Abstract To investigate the time-dependent effects of acrylamide (ACR) on the antioxidative status in rat nerve tissues, adult male Wistar rats were given ACR (40 mg/kg, i.p., 3 times/week) for 2, 4, 6 and 10 weeks, respectively. The time-dependent changes of the lipid peroxidation (malondialdehyde, MDA) and antioxidative status (glutathione, GSH; glutathione peroxidase, GSH-Px; glutathione reductase, GR; superoxide dismutase, SOD and anti-reactive oxygen species, anti-ROS) in nerve tissues were investigated. The electrophysiology indices (nerve conduction velocity, NCV; compound action potential duration, CAPD; compound action potential amplitude, CAPA; compound action potential latency, CAPL) in the sciatic nerve were determined using BL-420E Biologic Function Determining System. The results showed that MDA levels increased significantly (P P P P P P r| > 0.80) with the electrophysiology indices according to the exposure time. Thus, ACR-induced neurotoxicity may be associated with the enhancement of lipid peroxidation and reduction of the antioxidative capacity. Depletion of neural GSH level might be one of the primary events in ACR-induced neuropathy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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