التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of immune response to Hepatitis B vaccine in healthcare workers at a tertiary care hospital in Pakistan: an observationalprospective study. |
| المؤلفون: |
Zeeshan, Mohammad, Jabeen, Kauser, Ali, Anita Nausheen Akbar, Ali, Ailia Wilayat, Farooqui, Saadia Z., Mehraj, Vikram, Zafar, Afia |
| المصدر: |
BMC Infectious Diseases; 2007, Vol. 7 Issue 1, p120-125, 6p |
| مصطلحات موضوعية: |
IMMUNE response, HEPATITIS B vaccines, MEDICAL personnel, PREVENTION of communicable diseases |
| مصطلحات جغرافية: |
PAKISTAN |
| مستخلص: |
Background: Seroconversion rates reported after Hepatitis B virus (HBV) vaccination globally ranges from 85-90%. Health care workers (HCWs) are at high risk of acquiring HBV and non responders' rates after HBV vaccination were not reported previously in Pakistani HCWs. Therefore we evaluated immune response to HBV vaccine in HCWs at a tertiary care hospital in Karachi, Pakistan. Methods: Descriptive observational study conducted at Aga Khan University from April 2003 to July 2004. Newly HBV vaccinated HCWs were evaluated for immune response by measuring serum Hepatitis B surface antibody (HBsAb) levels, 6 weeks post vaccination. Results: Initially 666 employees were included in the study. 14 participants were excluded due to incomplete records. 271 (41%) participants were females and 381(59%) were males. Majority of the participants were young (<25-39 years old), regardless of gender. Out of 652 HCWs, 90 (14%) remained seronegative after six weeks of post vaccination. The percentage of non responders increased gradually from 9% in participants of <25, 13% in 25-34, 26% in 35-49, and 63% in >50 years of age. Male non responders were more frequent (18%) than female (8%). Conclusion: Seroconversion rate after HBV vaccination in Pakistani HCWs was similar to that reported in western and neighboring population. HCWs with reduced immune response to HBV vaccine in a high disease prevalent population are at great risk. Therefore, it is crucial to check post vaccination HBsAb in all HCWs. This strategy will ensure safety at work by reducing nosocomial transmission and will have a cost effective impact at an individual as well as at national level, which is very much desired in a resource limited country. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Infectious Diseases is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder