التفاصيل البيبلوغرافية
| العنوان: |
Vitiligo following a combined liver-kidney transplant. |
| المؤلفون: |
Victoria Bradley, Elizabeth Helen Kemp, Claire Dickinson, Tim Key, Paul Gibbs, Menna R. Clatworthy |
| المصدر: |
Nephrology Dialysis Transplantation; Feb2009, Vol. 24 Issue 2, p686-686, 1p |
| مصطلحات موضوعية: |
VITILIGO, KIDNEY transplantation, LIVER transplantation, AUTOIMMUNITY, ADRENOCORTICAL hormones, IMMUNOSUPPRESSION, MELANOCYTES, BONE marrow transplantation |
| مستخلص: |
We report an Afro-Caribbean male who developed vitiligo 10 days following a combined liver–kidney transplant from a Caucasian donor. Neither the donor nor the recipient had any previous history of vitiligo, nor of autoimmunity. The depigmentation gradually resolved by 8 weeks post-transplant with topical corticosteroids and standard maintenance immunosuppression. We propose that the skin depigmentation occurred due to the destruction of melanocytes by donor-derived alloreactive cytotoxic T-lymphocytes or antibody transferred during transplantation. Although vitiligo has been described in patients receiving allogeneic bone marrow transplantation for haematological malignancy, there are no previous reports of vitiligo post-solid organ transplantation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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