التفاصيل البيبلوغرافية
| العنوان: |
Long-term survival in primary CNS lymphoma treated by high-dose methotrexate monochemotherapy: role of STAT6 activation as prognostic determinant. |
| المؤلفون: |
Seung-Ho Yang, Kun Lee, Il Kim, Jae Hong, Jae Sung, Byung Son, Sang Lee, Yong-Kil Hong |
| المصدر: |
Journal of Neuro-Oncology; Mar2009, Vol. 92 Issue 1, p65-71, 7p |
| مستخلص: |
Abstract We report a single-center experience of 16 immunocompetent patients diagnosed with primary central nervous system lymphoma and treated with monochemotherapy with high-dose methotrexate (MTX) and deferred radiotherapy. MTX was given at a dose of 8.0 g/m2 for induction and at a dose of 3.5–8.0 g/m2 for maintenance. There were eight complete responses (CR), one partial response, one stable disease, and six patients whose tumors progressed in spite of the chemotherapy. At final follow-up, five of five CRs were alive and well without radiotherapy, with median follow-up of 26 months. Overall survival in eight non-CRs treated with the subsequent radiotherapy was 36 months. In the immunohistochemical study, STAT6 was positively expressed in 8 out of 13 cases. They included all non-CRs and two CRs. This observation suggests that STAT6 expression can be used as a prognostic determinant for MTX chemotherapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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