التفاصيل البيبلوغرافية
| العنوان: |
GENOTOXIC EFFECT OF 2,4,6-TRICHLOROPHENOL ON P53 GENE IN ZEBRAFISH LIVER. |
| المؤلفون: |
DAQIANG YIN, HANKAI ZHU, PING HU, QINGSHUN ZHAO |
| المصدر: |
Environmental Toxicology & Chemistry; Mar2009, Vol. 28 Issue 3, p603-608, 6p, 2 Charts |
| مصطلحات موضوعية: |
GENETIC toxicology, TRICHLOROPHENOL, ZEBRA danio, CARCINOGENS research, CARCINOGENICITY testing, HIGH performance liquid chromatography, NUCLEOTIDE sequence, LIVER diseases, CARCINOGENESIS, PHYSIOLOGY |
| مستخلص: |
Trichlorophenol (2,4,6-trichlorophenol [TCP]), a probable human carcinogen, is widely present in the environment. Employing denaturing high-performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10-d exposure of zebrafish to TCP at 5 μg/L resulted in elevated point mutations of p53 gene in the liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in the somatic genome. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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