التفاصيل البيبلوغرافية
| العنوان: |
Soy Isoflavones Modulate Azoxymethane-Induced Rat Colon Carcinogenesis Exposed Pre- and Postnatally and Inhibit Growth of DLD-1 Human Colon Adenocarcinoma Cells by Increasing the Expression of Estrogen Receptor-β. |
| المؤلفون: |
Raju, Jayadev, Bielecki, Agnieszka, CaIdwell, Donald, Lok, Eric, Taylor, Marnie, Kapal, Kamla, Curran, Ivan, Cooke, Gerard M., Bird, Ranjana P., Mehta, Rekha |
| المصدر: |
Journal of Nutrition; Mar2009, Vol. 139 Issue 3, p474-481, 8p, 1 Chart, 6 Graphs |
| مصطلحات موضوعية: |
ISOFLAVONES, SOYFOODS, SOYBEAN products, COLON cancer, ESTROGEN receptors, ADENOCARCINOMA, CANCER cells, RATS |
| مستخلص: |
We studied the effects of lifetime exposure to dietary soy isoflavones in an azoxymethane (AOM)-induced rat colon cancer model. Male pups born to Sprague-Dawley rats exposed (including during pregnancy and lactation) to soy isoflavones at either no 10 mg = control), low 140 mg), or high (1000 mg) doses/kg diet were weaned and continued receiving their respective parental diets until the end of the study. Weaned rats received 2 subcutaneous injections (15 mg/kg body weight) of AOM 1 wk apart. After 26 wk, rats were killed and the coordinates of colon aberrant crypt foci (ACF) and tumors were determined. Expression of estrogen receptor (ER)-β was assessed in rat colon tumors and in DLD-1 human colon adenocarcinoma cells exposed to soy isoflavones. Compared with the control, soy isoflavones did not affect incidences or multiplicities of colon ACF or tumors. Low-dose soy isoflavones decreased tumor burden and size compared with the control (P< 0.05). Expression of ERβ increased in colon tumors of soy isoflavone-treated groups compared with the control. Soy isoflavones dose-dependently arrested the growth of DLD-1 cells and at subcytotoxic levels increased the expression of ERβ. Our results suggest that pre- and postnatal exposure to dietary soy isoflavones suppresses the growth of colon tumors in male rats. The overexpression of ERβ in both rat colon tumors and DLD-1 cells caused by soy isoflavones suggests that ERβ is a critical mediator in mitigating its cancer-preventive effects. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
