التفاصيل البيبلوغرافية
| العنوان: |
The role of stem cell factor and granulocyte-colony stimulating factor in brain repair during chronic stroke. |
| المؤلفون: |
Chun-Shu Piao, Gonzalez-Toledo, Maria E., Yue-Qiang Xue, Wei-Ming Duan, Terao, Satoshi, Granger, D. Neil, Kelley, Roger E., Li-Ru Zhao |
| المصدر: |
Journal of Cerebral Blood Flow & Metabolism; Apr2009, Vol. 29 Issue 4, p759-770, 12p, 1 Color Photograph, 1 Black and White Photograph, 1 Diagram, 3 Graphs |
| مصطلحات موضوعية: |
CEREBROVASCULAR disease, NEUROLOGY, STEM cells, GRANULOCYTES, BONE marrow, CELLS |
| مستخلص: |
Chronic stroke is a highly important but under-investigated scientific problem in neurologic research. We have reported earlier that stem cell factor (SCF) in combination with granulocyte-colony stimulating factor (G-CSF) treatment during chronic stroke improves functional outcomes. Here we have determined the contribution of bone marrow-derived cells in angiogenesis and neurogenesis, which are enhanced by SCF+G-CSF treatment during chronic stroke. Using bone marrow tracking, flow cytometry, 2-photon live brain imaging, and immunohistochemistry, we observed that the levels of circulating bone marrow stem cells (BMSCs) (CD34+/c-kit+) were significantly increased by SCF+G-CSF treatment. In addition, live brain imaging revealed that numerous bone marrow-derived cells migrate into the brain parenchyma in the treated mice. We also found that bone marrow-derived cells, bone marrow-derived endothelial cells, vascular density, and bone marrow-derived neurons were significantly augmented by SCF+G-CSF. It is interesting that, in addition to the increase in bone marrow-derived endothelial cells, the number of bone marrow-derived pericytes was reduced after SCF+G-CSF treatment during chronic stroke. These data suggest that SCF+G-CSF treatment can enhance repair of brain damage during chronic stroke by mobilizing BMSCs, and promoting the contribution of bone marrow-derived cells to angiogenesis and neurogenesis.Journal of Cerebral Blood Flow & Metabolism (2009) 29, 759–770; doi:10.1038/jcbfm.2008.168; published online 11 February 2009 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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