التفاصيل البيبلوغرافية
| العنوان: |
Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from4,5-Dichloro-1H-Imidazole. |
| المؤلفون: |
Medvetz, Doug A., Hindi, Khadijah M., Panzner, Matthew J., Ditto, Andrew J., Yun, Yang H., Youngs, Wiley J. |
| المصدر: |
Metal-Based Drugs; 2008, p1-7, 7p, 15 Color Photographs, 1 Diagram, 1 Chart, 1 Graph |
| مصطلحات موضوعية: |
ANTINEOPLASTIC agents, CARBENES, IMIDAZOLES, CANCER cells, CELL lines, HELA cells |
| مستخلص: |
A class of Ag(I) N-heterocyclic carbene silver complexes, 1-3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1-3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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