دورية أكاديمية

Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.

التفاصيل البيبلوغرافية
العنوان: Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.
المؤلفون: Maria Sampaio, Paulo Cecon, Manuel de Jesus Simões, Marair Sartori, Manoel Girão
المصدر: International Urogynecology Journal; Jan2010, Vol. 21 Issue 1, p111-116, 6p
مصطلحات موضوعية: ISOFLAVONES, PLANT extracts, SOYBEAN, UTERUS, URETHRA, OVARIECTOMY, LABORATORY rats
مستخلص: Abstract Objective  To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats. Methods  Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 μg genistein/g body weight/day, with a soy-free diet. Average numbers of nuclei (NU), blood vessels (BV) and collagen fibers (CF) in uterus and mid-urethra sections were compared using Dunnett and Tukey tests (95% CI). Results  Uterus: GII and GIII differed from GI in all respects; GII vs. GIII, no differences. Urethra: GIII vs. GI: no differences; GII vs. GI, differences in NU and CF; GII vs. GIII, differences in NU and CF. Conclusions  Early oral administration of SIE to ovariectomized rats reversed uterine/urethral effects of castration. [ABSTRACT FROM AUTHOR]
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