التفاصيل البيبلوغرافية
| العنوان: |
Western diet increases wheel running in mice selectively bred for high voluntary wheel running. |
| المؤلفون: |
Meek, T. H., Eisenmann, J. C., Garland, Jr., T. |
| المصدر: |
International Journal of Obesity; Jun2010, Vol. 34 Issue 6, p960-969, 10p, 4 Charts, 3 Graphs |
| مصطلحات موضوعية: |
MICE, OBESITY, BODY weight, FOOD consumption, LIPIDS |
| مستخلص: |
Objective:Mice from a long-term selective breeding experiment for high voluntary wheel running offer a unique model to examine the contributions of genetic and environmental factors in determining the aspects of behavior and metabolism relevant to body-weight regulation and obesity. Starting with generation 16 and continuing through to generation 52, mice from the four replicate high runner (HR) lines have run 2.5–3-fold more revolutions per day as compared with four non-selected control (C) lines, but the nature of this apparent selection limit is not understood. We hypothesized that it might involve the availability of dietary lipids.Methods:Wheel running, food consumption (Teklad Rodent Diet (W) 8604, 14% kJ from fat; or Harlan Teklad TD.88137 Western Diet (WD), 42% kJ from fat) and body mass were measured over 1–2-week intervals in 100 males for 2 months starting 3 days after weaning.Results:WD was obesogenic for both HR and C, significantly increasing both body mass and retroperitoneal fat pad mass, the latter even when controlling statistically for wheel-running distance and caloric intake. The HR mice had significantly less fat than C mice, explainable statistically by their greater running distance. On adjusting for body mass, HR mice showed higher caloric intake than C mice, also explainable by their higher running. Accounting for body mass and running, WD initially caused increased caloric intake in both HR and C, but this effect was reversed during the last four weeks of the study. Western diet had little or no effect on wheel running in C mice, but increased revolutions per day by as much as 75% in HR mice, mainly through increased time spent running.Conclusion:The remarkable stimulation of wheel running by WD in HR mice may involve fuel usage during prolonged endurance exercise and/or direct behavioral effects on motivation. Their unique behavioral responses to WD may render HR mice an important model for understanding the control of voluntary activity levels. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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