التفاصيل البيبلوغرافية
| العنوان: |
A double-blind, placebo-controlled steroid-sparing study with budesonide Turbuhaler in Japanese oral steroid-dependent asthma patients. |
| المؤلفون: |
Selroos, Olof, Miyamoto, Terumasa, Takahashi, Terumi, Nakajima, Shigenori, Makino, Sohei, Yamakido, Michio, Mano, Kenji, Nakashima, Mitsuyoshi, Tollemar, Ulf |
| المصدر: |
Respirology; Sep2000, Vol. 5 Issue 3, p231-240, 10p |
| مصطلحات موضوعية: |
ASTHMA treatment, STEROID drugs |
| مستخلص: |
Objective:The aim of this study was to evaluate the oral steroid-sparing capacity of budesonide Turbuhaler®. Methodology:One hundred and thirteen oral steroid-dependent patients were treated for 6 months with placebo or budesonide 800 μg or 1600 μg daily. Every second week the oral steroid dose was reduced if asthma control permitted. Results:The reductions in oral steroid doses were 9, 35 and 60% in the placebo and budesonide 800 μg and 1600 μg groups, respectively. Oral steroid treatment could be discontinued in 4% (placebo), 15% (800 μg) and 23% (1600 μg). Mean peak expiratory flow values increased by 21 and 24 L/min in the budesonide groups but decreased by 6 L/min in the placebo group. Asthma attack, activity and sleep scores remained unchanged showing maintained efficacy. Plasma cortisol levels increased and an adrenocorticotropic hormone test showed improved adrenocortical response in both budesonide groups, indicating improved safety. Adverse drug reactions were infrequent and mild in all study groups. Conclusion:Budesonide Turbuhaler, 800 μg and 1600 μg daily, resulted in a significant reduction in oral steroid usage in steroid-dependent patients. The effect was achieved with maintained asthma control together with improvements in lung and adrenal functions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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