التفاصيل البيبلوغرافية
| العنوان: |
Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains. |
| المؤلفون: |
Calmels, S., Ohshima, H., Vincent, P., Gounot, A.-M., Bartsch, H. |
| المصدر: |
Carcinogenesis; 1985, Vol. 6 Issue 6, p911-915, 5p |
| مستخلص: |
Thirty-eight strains of microorganisms isolated from infected human trachea, urine, blood and faeces were examined for their ability to form N-nitrosomorpholine from morpholine and nitrite at pH 7.25. Twenty-five bacterial strains exhibited nitrosation activity, including 18 out of 19 strains of and three out of nine and A10 strain showed the highest activity. Formation of N-nitrosomorpholine was proportional to the incubation time up to 2 h and to the number of resting A10 cells; the reaction followed Michaelis-Menten kinetics. Nitrosation rate appeared to be dependent on the value of several amines studied. As the nitrosation catalysis was heat-labile, our data suggest that N-nitrosation is catalysed by a bacterial enzyme(s). This reaction may lead to enhanced endogenous nitrosation in subjects suffering from an achlorhydric stomach or from chronk urinary tract infections. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
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