التفاصيل البيبلوغرافية
| العنوان: |
A clinical dose-response study of bacampicillin in uncomplicated gonorrhoea. |
| المؤلفون: |
Bengtsson, Stellan, Erikson, Gunnel, Kallings, Lars-Olof, Moberg, Ingegerd, Sandström, Eric, Wallin, Johan, Wallmark, Gösta, Bengtsson, S, Erikson, G, Kallings, L O, Moberg, I, Sandström, E, Wallin, J, Wallmark, G |
| المصدر: |
Journal of Antimicrobial Chemotherapy (JAC); Mar1979, Vol. 5 Issue 2, p211-218, 8p |
| مصطلحات موضوعية: |
CLINICAL trials, COMPARATIVE studies, DOSE-effect relationship in pharmacology, GONORRHEA, RESEARCH methodology, MEDICAL cooperation, RESEARCH, TIME, EVALUATION research, RANDOMIZED controlled trials, AMPICILLIN, THERAPEUTICS |
| مستخلص: |
In a double-blind study of dose-response, 883 cases with uncomplicated gonorrhoea were given single oral doses of 400, 800 or 1600 mg bacampicillin, with 1 g probenecid. Eight hundred and 1600 mg were equally effective with negative cultures in 98.2% and 99.7% of the patients, respectively; 400 mg gave negative cultures in 95.2%. The differences between the lowest dose and the two others were statistically significant. In patients with less sensitive strains, the highest dose was superior. It is concluded that a single dose of bacampicillin 800 mg plus probenecid 1 g was effective in uncomplicated gonorrhoea with fully ampicillin-sensitive strains. In patients with gonococci showing reduced sensitivity to anipicillin the best results, 96.3%, were achieved with the double dose of bacampicillin. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
Complementary Index |
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