التفاصيل البيبلوغرافية
العنوان: |
In-vitro susceptibility of the Bacteroides fragilis group and the inoculum effect of newer beta-lactam antibiotics on this group of organisms. |
المؤلفون: |
Jacobus, Nilda V., Cuchural, George J., Tally, Francis P., Jacobus, N V, Cuchural, G J Jr, Tally, F P |
المصدر: |
Journal of Antimicrobial Chemotherapy (JAC); Nov1989, Vol. 24 Issue 5, p675-682, 8p |
مصطلحات موضوعية: |
ANTIBIOTICS, BETA lactam antibiotics, CULTURE media (Biology), MICROBIAL sensitivity tests, GRAM-negative anaerobic bacteria, PHARMACODYNAMICS |
مستخلص: |
The susceptibility and inoculum effect of 190 selected Bacteroides fragilis group isolates were determined with six beta-lactam antibiotics by two different methods: agar dilution and broth microdilution. The results were analysed by species within this group of pathogens. The evaluation showed that imipenem had superior activity and was very stable to increased inoculum concentration. Cefoxitin and piperacillin exhibited very good activity and very small inoculum effect; latamoxef showed stability to changes in the inoculum concentration but only intermediate activity; while ceftizoxime and cefoperazone exhibited a marked inoculum effect and relatively poor activity. Resistance among the species was as follows: B. distasonis greater than B. thetaiotaomicron greater than B. ovatus greater than B. fragilis. The inoculum effect was higher when tests were performed in broth rather than in agar. In general, the effect was more pronounced among B. ovatus and less among B. distasonis isolates. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |