التفاصيل البيبلوغرافية
العنوان: |
A comparative assessment of vancomycin-associated nephrotoxicity in the young versus the elderly hospitalized patient. |
المؤلفون: |
Vance-Bryan, Kyle, Rotschafer, John C., Gilliland, Susan S., Rodvold, Keith A., Fitzgerald, Colleen M., Guay, David R. P., Vance-Bryan, K, Rotschafer, J C, Gilliland, S S, Rodvold, K A, Fitzgerald, C M, Guay, D R |
المصدر: |
Journal of Antimicrobial Chemotherapy (JAC); Apr1994, Vol. 33 Issue 4, p811-821, 11p |
مستخلص: |
The incidence of vancomycin-associated nephrotoxicity was determined in a younger (age < 60 y) elderly (age ≥ 60 y) hospitalized adult population to identify associated drug- and nondrug-related risk factors. Nephrotoxicity was defined as an acute increase in serum creatinine of ≥ 44⋅2 μimol/L if baseline serum creatinine was ≤ 221 μimol/L or an increase in serum creatinine of ≥ 88⋅4 μimol/L if baseline serum creatinine > 221 μimol/L. A total of 289 patients, 141 younger (mean age,±S.D. 37⋅9 ± 12⋅4 y) and 148 elderly (73⋅6 ± 8⋅5 years), was retrospectively reviewed. Nephrotoxicity occurred in 7⋅8% younger vs 18⋅9% elderly patients ( = 0⋅003). Using multivariate logistic regression models for the pooled patient population, concurrent loop diuretic use was significantly associated with vancomycin-associated nephrotoxicity (relative risk (R.R.) = 5⋅06); for the younger population, only concurrent amphotericin B use was significantly associated with vancomycin-associated nephrotoxicity (R.R. = 6˙65); and for the elderly population, only concurrent loop diuretic use was significantly associated with vancomycin-associated nephrotoxicity (R.R. = 9⋅70). These data suggest that elderly patients are at significantly greater risk of vancomycin-associated nephrotoxicity than are younger patients. However, because age was not a significant risk factor for nephrotoxicity in comparing the pooled vancomycin-associated nephrotoxicity group compared to the non-nephrotoxicity group, the differences observed between age groups probably reflect differences in risk factor prevalence. [ABSTRACT FROM PUBLISHER] |
|
Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |