التفاصيل البيبلوغرافية
| العنوان: |
A comparative assessment of vancomycin-associated nephrotoxicity in the young versus the elderly hospitalized patient. |
| المؤلفون: |
Vance-Bryan, Kyle, Rotschafer, John C., Gilliland, Susan S., Rodvold, Keith A., Fitzgerald, Colleen M., Guay, David R. P., Vance-Bryan, K, Rotschafer, J C, Gilliland, S S, Rodvold, K A, Fitzgerald, C M, Guay, D R |
| المصدر: |
Journal of Antimicrobial Chemotherapy (JAC); Apr1994, Vol. 33 Issue 4, p811-821, 11p |
| مستخلص: |
The incidence of vancomycin-associated nephrotoxicity was determined in a younger (age < 60 y) elderly (age ≥ 60 y) hospitalized adult population to identify associated drug- and nondrug-related risk factors. Nephrotoxicity was defined as an acute increase in serum creatinine of ≥ 44⋅2 μimol/L if baseline serum creatinine was ≤ 221 μimol/L or an increase in serum creatinine of ≥ 88⋅4 μimol/L if baseline serum creatinine > 221 μimol/L. A total of 289 patients, 141 younger (mean age,±S.D. 37⋅9 ± 12⋅4 y) and 148 elderly (73⋅6 ± 8⋅5 years), was retrospectively reviewed. Nephrotoxicity occurred in 7⋅8% younger vs 18⋅9% elderly patients ( = 0⋅003). Using multivariate logistic regression models for the pooled patient population, concurrent loop diuretic use was significantly associated with vancomycin-associated nephrotoxicity (relative risk (R.R.) = 5⋅06); for the younger population, only concurrent amphotericin B use was significantly associated with vancomycin-associated nephrotoxicity (R.R. = 6˙65); and for the elderly population, only concurrent loop diuretic use was significantly associated with vancomycin-associated nephrotoxicity (R.R. = 9⋅70). These data suggest that elderly patients are at significantly greater risk of vancomycin-associated nephrotoxicity than are younger patients. However, because age was not a significant risk factor for nephrotoxicity in comparing the pooled vancomycin-associated nephrotoxicity group compared to the non-nephrotoxicity group, the differences observed between age groups probably reflect differences in risk factor prevalence. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
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