التفاصيل البيبلوغرافية
| العنوان: |
Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome. |
| المؤلفون: |
Azevedo Lucio, Eraldo de, Gonçalves, Sandro C., Ribeiro, Jorge P., Nunes, Gilberto L., Oliveira, Jarbas R. de, Araujo, Gustavo N., Wainstein, Marco V. |
| المصدر: |
Inflammation Research; Feb2011, Vol. 60 Issue 2, p137-142, 6p |
| مستخلص: |
Objective: To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS). Design and methods: This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease. Results: A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4-73.5 ng/mL) and 10 (0-87.5), respectively. Spearman's correlation coefficient did not show a significant association between MPO levels and Gensini scores ( r = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥2 × ULN (upper limit of normal), TIMI risk score ≥4 and Gensini score in the multivariate analysis. Conclusion: Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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