التفاصيل البيبلوغرافية
| العنوان: |
Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo. |
| المؤلفون: |
Rose-John, S., Fürstenberger, G., Krieg, P., Besemfelder, E., Rincke, G., Marks, F. |
| المصدر: |
Carcinogenesis; 1988, Vol. 9 Issue 5, p831-835, 5p |
| مستخلص: |
Hyperplasiogenic and tumor-promoting phorbol esters such as 12--tetradecanoylphorbol-13-acetate or l2--retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes and and the ornithine decarboxylase gene in mouse skin . This sequence of biochemical events probably depends on an activation of protein kinase C by these agents. The non-irritant skin mitogens 4--methyl-12--tetradecanoylphorbol-13-acetate and ethyl phenyl propiolate do not increase the expression of these genes to a comparable extent. Thus, 12--tetradecanoylphorbol-13-acetate and 12--retinoylphorbol-13-acetate induce epidermal hyperproliferation by different biochemical mechanisms as do 4--methyl-12--tetradecanoylphorbol-13-acetate and ethyiphenyipropiolate. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
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