التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. |
| المؤلفون: |
Fan Wang, Cheng-Qi Xu, Qing He, Jian-Ping Cai, Xiu-Chun Li, Dan Wang, Xin Xiong, Yu-Hua Liao, Qiu-Tang Zeng, Yan-Zong Yang, Xiang Cheng, Cong Li, Rong Yang, Chu-Chu Wang, Gang Wu, Qiu-Lun Lu, Ying Bai, Yu-Feng Huang, Dan Yin, Qing Yang |
| المصدر: |
Nature Genetics; Apr2011, Vol. 43 Issue 4, p345-349, 5p, 3 Charts, 1 Graph |
| مصطلحات موضوعية: |
CORONARY disease, GENOMES, GENOMICS, LOCUS (Genetics), MESSENGER RNA |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10?3, stage 2 validation; P = 3.00 × 10?3, P = 1.19 × 10?8 and P = 4.00 × 10?3 in three independent stage 3 replication populations; P = 4.87 × 10?12, odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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