التفاصيل البيبلوغرافية
| العنوان: |
Classification of viral zoonosis through receptor pattern analysis. |
| المؤلفون: |
Se-Eun Bae, Hyeon Seok Son |
| المصدر: |
BMC Bioinformatics; 2011, Vol. 12 Issue 1, p96-102, 7p |
| مصطلحات موضوعية: |
VIRUSES, PROTEINS, RNA viruses, AMINO acid sequence, GENETIC mutation |
| مستخلص: |
Background: Viral zoonosis, the transmission of a virus from its primary vertebrate reservoir species to humans, requires ubiquitous cellular proteins known as receptor proteins. Zoonosis can occur not only through direct transmission from vertebrates to humans, but also through intermediate reservoirs or other environmental factors. Viruses can be categorized according to genotype (ssDNA, dsDNA, ssRNA and dsRNA viruses). Among them, the RNA viruses exhibit particularly high mutation rates and are especially problematic for this reason. Most zoonotic viruses are RNA viruses that change their envelope proteins to facilitate binding to various receptors of host species. In this study, we sought to predict zoonotic propensity through the analysis of receptor characteristics. We hypothesized that the major barrier to interspecies virus transmission is that receptor sequences vary among species-in other words, that the specific amino acid sequence of the receptor determines the ability of the viral envelope protein to attach to the cell. Results: We analysed host-cell receptor sequences for their hydrophobicity/hydrophilicity characteristics. We then analysed these properties for similarities among receptors of different species and used a statistical discriminant analysis to predict the likelihood of transmission among species. Conclusions: This study is an attempt to predict zoonosis through simple computational analysis of receptor sequence differences. Our method may be useful in predicting the zoonotic potential of newly discovered viral strains. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Bioinformatics is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder