التفاصيل البيبلوغرافية
| العنوان: |
SYNTHESIS OF 7-SUBSTITUTED 3-β-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES. |
| المؤلفون: |
Karskela, Tuomas, Klika, Karel D., Lönnberg, Harri |
| المصدر: |
Collection of Czechoslovak Chemical Communications; 2011, Vol. 76 Issue 8, p1043-1054, 12p, 2 Diagrams |
| مصطلحات موضوعية: |
NUCLEOSIDES, HETEROCYCLIC compounds, IMIDAZOLES, PURINES, ACYLATION, ALKYLATION, NUCLEAR magnetic resonance spectroscopy |
| مستخلص: |
A method for the synthesis of 7-substituted 3-β-D-ribofuranosyl-3H-imidazo[2,1-i]purines has been devised whereby compounds were prepared in a few steps from a common intermediate, 3-(2′,3′-O-isopropylidene-β-D-ribofuranosyl)-3H-imidazo[2,1-i]purine-7-carbaldehyde, obtained from the reaction of 2′,3′-O-isopropylideneadenosine with bromomalonaldehyde. The formyl group of the carbaldehyde was subsequently reductively aminated and the resulting secondary amines were then further derivatized either by acylation, lactamization or reductive alkylation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
