التفاصيل البيبلوغرافية
| العنوان: |
FATE OF PATIENTS WITH LATE-DETECTED HEPATITIS C INFECTION - CASE REPORTS. |
| Alternate Title: |
SUDBINA BOLESNIKA SA KASNO OTKRIVENOM HEPATITIS C INFEKCIJOM - PRIKAZ BOLESNIKA. (Polish) |
| المؤلفون: |
Kostić, Velimir, Jovanović, Branislav, Petrović, Aleksandar, Radović, Jelana, Kostić, Jovana, Vujić, Stevan, Popović, Lidija |
| المصدر: |
Acta Medica Medianae; Jun2011, Vol. 50 Issue 2, p49-52, 4p |
| مصطلحات موضوعية: |
HEPATITIS C diagnosis, ANTIVIRAL agents, ORGAN donation |
| Abstract (English): |
Chronic hepatitis C virus infection represents an insidious disease that is often detected with signs of liver cirrhosis or hepatocellular carcinoma. It is practicaly impossible to achieve a significant therapeutic progress in these patients without performing a liver transplantation. However, due to underdeveloped program of organ donations, this kind of intervention, as the last helpful procedure, is often not realized. This study presents three patients (out of 121 treated patients) followed during a two-year period. The patients had been initially registered when the stage of their disease became severe: liver failure with signs of decompensation. Antiviral therapy (pegylated interferon and ribavirin) in these patients have no use, hence only a corrective therapy is administered. Pathohistological findings in two patients revealed hepatocellular carcinoma, and in one case lethal outcome was the result of severe hepatic decompensation, hepatopulmonary and hepatorenal syndromes, as well as developed cardiopulmonary failure. Lethal outcome occurred in the period of 2 to 14 months after the first visit to a doctor. One patient was on the list for liver transplantation; however, surgery was not performed and soon after a fatal outcome ensued. [ABSTRACT FROM AUTHOR] |
| Abstract (Polish): |
Hronični virusni hepatitis C predstavlja podmuklu bolest koja se često otkriva u vreme prisutnih promena, tipa ciroze jetre ili hepatocelularnog karcinoma. Kod ovih bolesnika praktično ne može biti učinjen značajan terapijski pomak, izuzev realizovanja transplantacije jetre. Međutim, zbog nedovoljno razvijenog donatorstva organa, ovakva intvencija, kao poslednji spasonosni zahvat, često se ne realizuje. U radu su prikazana tri bolesnika (od 121-og lečenog bolesnika) praćena tokom dvogodišnjeg perioda. Bolesnici su prvi put registrovani kada je njihova bolest imala težak stepen: insuficijenciju jetre sa znacima dekompenzacije. Antivirusna terapija (pegilovanim interferonom i ribavirinom) kod ovakvih bolesnika nema primenu, te je samo sprovođena korektivna terapija. Kod dva bolesnika je patohistološkom obradom dokazno prisustvo hepatocelularnog karcinoma, dok je kod jedne bolesnice smrtni ishod nastao usled teške dekompenzacije jetre, pojave hepatopulmonalnog i hepatorenalnog sindroma i razvoja kardiopulmonalne slabosti. Smrtni ishod je kod bolesnika nastupio u periodu od dva do 14 meseci od momenta prvog susreta. Jedna od prikaznih bolesnica bila je na listi za transplantaciju jetre, međutim, operacija nije izvedena i nedugo zatim usledio je smrtni ishod. [ABSTRACT FROM AUTHOR] |
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