التفاصيل البيبلوغرافية
| العنوان: |
Restricted expression of anti-type II collagen antibody isotypes in mice suppressed for collagen-induced arthritis. |
| المؤلفون: |
Kresina, T F, Finegan, C K |
| المصدر: |
Annals of the Rheumatic Diseases; Jan1986, Vol. 45 Issue 1, p60-66, 7p |
| مصطلحات موضوعية: |
ANIMAL experimentation, ARTHRITIS, COLLAGEN, COMPARATIVE studies, IMMUNOGLOBULINS, RESEARCH methodology, MEDICAL cooperation, MICE, RADIOIMMUNOASSAY, RESEARCH, RESEARCH funding, EVALUATION research, ANTIBODY formation |
| مستخلص: |
The present study details the time course and isotype distribution of the immune response to type II collagen in collagen-induced arthritic mice and mice suppressed for collagen-induced arthritis. The serum of arthritic mice was observed to contain significantly higher (p less than 0.005) concentrations of antibodies to type II collagen than that of mice suppressed for arthritis at all times tested. For the arthritic mice anti-type II collagen antibodies ranged from 0.2 +/- 0.2 (SD) to 6.1 +/- 0.7 mg/ml (g/l). Serum values for mice suppressed for arthritis ranged from 0.05 +/- 0.04 to 0.6 +/- 0.04 mg/ml. Analysis of the isotypes of these responses showed an expression of anticollagen molecules restricted to the IgG1 subclass in mice suppressed for collagen arthritis throughout the time course (p less than 0.01). The data indicate that mice suppressed for collagen-induced arthritis can mount a primary and secondary immune response to the arthrogenic stimuli. This response, however, is mainly restricted to the IgG1 subclass of antibodies. This restricted subclass expression of anticollagen antibodies may represent a mechanism of suppression of arthritis in the murine model of collagen-induced arthritis. [ABSTRACT FROM AUTHOR] |
|
Copyright of Annals of the Rheumatic Diseases is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder