التفاصيل البيبلوغرافية
| العنوان: |
Metallo-β-lactamase-producing Clinical Isolates from Patients of a Tertiary Care Hospital. |
| المؤلفون: |
Deshmukh, Durgesh Gopalrao, Damle, Ajit S., Bajaj, Jyoti K., Bhakre, Jayshree B., Patwardhan, Neeta S. |
| المصدر: |
Journal of Laboratory Physicians; Jul-Dec2011, Vol. 3 Issue 2, p93-97, 5p, 3 Charts |
| مصطلحات موضوعية: |
ANTIBIOTICS, DRUG resistance in microorganisms, ENTEROBACTERIACEAE, BACTERIAL diseases, BETA lactamases, DISEASE prevalence, MULTIDRUG resistance |
| مستخلص: |
Background: The growing increase in the rates of antibiotic resistance is a major cause for concern in both non-fermenting bacilli and isolates of the Enterobacteriaceae family. β-lactams have been the mainstay of treatment for serious infections, and the most active of these are the carbapenems. Acquired metallo-β-lactamases (MBL) have recently emerged as one of the most worrisome resistance mechanisms owing to their capacity to hydrolyze all β-lactams, including carbapenems. We have undertaken this investigation to ascertain the prevalence of MBL-producing nonfermenting bacilli and Enterobacteriaceae. Materials and Methods: The study was conducted over a period of 4 months in a 1200-bedded teaching hospital. Isolates included in the study were screened for imipenem resistance both by conventional methods and mini analytical profile index (miniAPI). The isolates that showed imipenem resistance were tested for MBL production by imipenem (IMP)-ethylenediaminetetraacetic acid combined disc test. Imipenem-resistant non-MBL isolates also tested for Modified Hodge test and AmpC β-lactamases production to detect other mechanisms of carbapenem resistance. Results: Of 638 gram negative bacilli isolates and 3.39% showed imipenem resistance, 2.9% showed MBL production, of which 1.7% were non-fermenters and 1.25% were Enterobacteriaceae, 0.3% showing non-MBL KPC carbapenemas. Most isolates were from the intensive care unit and from post-operative patients. Our findings show that there are significant numbers of isolates having MBL production along with multidrug resistance. There is a need for active surveillance to detect MBL producers. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Laboratory Physicians is the property of Scientific Scholar LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder