التفاصيل البيبلوغرافية
| العنوان: |
L-glutamine supplementation prevents myenteric neuron loss and has gliatrophic effects in the ileum of diabetic rats. |
| المؤلفون: |
Pereira, Renata, Tronchini, Eleandro, Tashima, Cristiano, Alves, Eder, Lima, Mariana, Zanoni, Jacqueline, Pereira, Renata Virginia Fernandes, Tronchini, Eleandro Aparecido, Tashima, Cristiano Massao, Alves, Eder Paulo Belato, Lima, Mariana Machado, Zanoni, Jacqueline Nelisis |
| المصدر: |
Digestive Diseases & Sciences; Dec2011, Vol. 56 Issue 12, p3507-3516, 10p |
| مصطلحات موضوعية: |
ETIOLOGY of diseases, DISEASE exacerbation, OXIDATIVE stress, IMMUNOHISTOCHEMISTRY, DIABETIC neuropathies, NEURONS, GLUTAMINE, NEUROPROTECTIVE agents, NEUROGLIA, ILEUM, LABORATORY rats, CELL metabolism, DIABETES complications, ILEUM innervation, ANIMAL experimentation, AUTONOMIC nervous system, BIOLOGICAL models, CELLS, COMPARATIVE studies, DIABETES, DIETARY supplements, RESEARCH methodology, MEDICAL cooperation, MICROSCOPY, RATS, RESEARCH, EVALUATION research, TREATMENT effectiveness, PREVENTION |
| مستخلص: |
Background: Peripheral neuropathy caused chronically by diabetes mellitus is related to exacerbation of oxidative stress and a significant reduction in important endogenous antioxidants. L: -Glutamine is an amino acid involved in defense mechanisms and is a substrate for the formation of glutathione, the major endogenous cellular antioxidant.Aim: This study investigated the effects of 2% L: -glutamine supplementation on peripheral diabetic neuropathy and enteric glia in the ileum in rats.Methods: Male Wistar rats were divided into four groups: normoglycemics (N), normoglycemics supplemented with L: -glutamine (NG), diabetics (D), and diabetics supplemented with L: -glutamine (DG). After 120 days, the ileums were processed for HuC/D and S100 immunohistochemistry. Quantitative and morphometric analysis was performed.Results: Diabetes significantly reduced the number of HuC/D-immunoreactive myenteric neurons per unit area and per ganglion in group D compared with normoglycemic animals (group N). L: -Glutamine (2%) prevented neuronal death induced by diabetes (group DG) compared with group D. The glial density per unit area did not change with diabetes (group D) but was significantly reduced after L: -glutamine supplementation (groups NG and DG). Ganglionic glial density was similar among the four groups. The neuronal area was not altered in groups D and DG. Glial size was reduced in group D; this was reversed by L: -glutamine supplementation (group DG).Conclusions: We concluded that 2% L: -glutamine had neuroprotective effects directly on myenteric neurons and indirectly through glial cells, which had gliatrophic effects. [ABSTRACT FROM AUTHOR] |
|
Copyright of Digestive Diseases & Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder