التفاصيل البيبلوغرافية
| العنوان: |
Natural history of human immunodeficiency virus infections in hemophiliacs: effects of T-cell subsets, platelet counts, and age. |
| المؤلفون: |
Eyster, M. Elaine, Gail, Mitchell H., Ballard, James D., Al-Mondhiry, Hamid, Goedert, James J., Eyster, M E, Gail, M H, Ballard, J O, Al-Mondhiry, H, Goedert, J J |
| المصدر: |
Annals of Internal Medicine; Jul87, Vol. 107 Issue 1, p1-6, 6p |
| مصطلحات موضوعية: |
HEMOPHILIACS, HIV, AGE distribution, AIDS, COMPARATIVE studies, HEMOPHILIA, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, RESEARCH, T cells, VIRAL antibodies, EVALUATION research, RELATIVE medical risk, LEUKOCYTE count, PLATELET count |
| مستخلص: |
Serial T-cell subsets and platelet counts were determined in a cohort of 84 hemophiliacs in whom time of seroconversion for human immunodeficiency virus (HIV) antibody could be ascertained. An abrupt decrease in the number of T-helper (T4) cells was seen in 9 patients 12 to 24 months before the acquired immunodeficiency syndrome (AIDS) was diagnosed (p = 0.0007 compared with those who did not develop AIDS). Thrombocytopenia also was associated with an increased risk for AIDS (p = 0.02), as was older age at the time of seroconversion (p = 0.03). Ten patients developed AIDS at 24 to 95 months after seroconversion, for a cumulative incidence (+/- SE) of 18.0% +/- 7.1% at 6 years. Hemophiliacs who had T4 cell counts of less than 200 cells/microL had a 50% +/- 16% cumulative incidence of AIDS within 2 years, indicating that decreasing or very low T4 cell counts have predictive value for the development of AIDS. Furthermore, the data suggest that thrombocytopenia and older age may be markers for a cofactor that increases the risk for AIDS in hemophiliacs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
