التفاصيل البيبلوغرافية
| العنوان: |
Tyrosine hydroxylase activity in the central nervous system of the crayfish, Pacifastacus leniusculus (Crustacea, Decapoda). |
| المؤلفون: |
Laxmyr, Lena |
| المصدر: |
Journal of Comparative Physiology B: Biochemical, Systemic & Environmental Physiology; Jul1985, Vol. 155 Issue 5, p603-609, 7p |
| مستخلص: |
Tyrosine hydroxylase, responsible for the formation of l-dopa from l-tyrosine, has been identified in the central nervous system of the crayfish, Pacifastacus leniusculus (Crustacea, Decapoda). It requires pterine as cofactor and is inhibited by a number of known tyrosine hydroxylase inhibitors; iron-chelators, tyrosine analogues and also by the catecholamines, dopamine and noradrenaline. Iron enhances the activity of the enzyme. It differs from the vertebrate tyrosine hydroxylase in having a more alkaline pH optimum and a higher affinity for the pterine cofactor. Kinetic studies were performed and K and V values are presented. Dopa formed was identified and quantitatively measured by high pressure liquid chromatography (HPLC) and electrochemical detection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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