التفاصيل البيبلوغرافية
| العنوان: |
Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment. |
| المؤلفون: |
Botting, KJ, Wang, KCW, Padhee, M, McMillen, IC, Summers-Pearce, B, Rattanatray, L, Cutri, N, Posterino, GS, Brooks, DA, Morrison, JL |
| المصدر: |
Clinical & Experimental Pharmacology & Physiology; Sep2012, Vol. 39 Issue 9, p814-823, 10p, 2 Diagrams, 1 Chart, 3 Graphs |
| مصطلحات موضوعية: |
HEART disease risk factors, FETAL growth retardation, LOW birth weight, HEART development, CELL proliferation, HEART cells, APOPTOSIS |
| مستخلص: |
1. World-wide epidemiological and experimental animal studies demonstrate that adversity in fetal life, resulting in intrauterine growth restriction, programmes the offspring for a greater susceptibility to ischaemic heart disease and heart failure in adult life. 2. After cardiogenesis, cardiomyocyte endowment is determined by a range of hormones and signalling pathways that regulate cardiomyocyte proliferation, apoptosis and the timing of multinucleation/terminal differentiation. 3. The small fetus may have reduced cardiomyocyte endowment owing to the impact of a suboptimal intrauterine environment on the signalling pathways that regulate cardiomyocyte proliferation, apoptosis and the timing of terminal differentiation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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