التفاصيل البيبلوغرافية
| العنوان: |
Bifunctional Silica-Coated Superparamagnetic FePt Nanoparticles for Fluorescence/MR Dual Imaging. |
| المؤلفون: |
Syu-Ming Lai, Tsiao-Yu Tsai, Chia-Yen Hsu, Jai-Lin Tsai, Ming-Yuan Liao, Ping-Shan Lai |
| المصدر: |
Journal of Nanomaterials; 2012, p1-7, 7p |
| مصطلحات موضوعية: |
SUPERPARAMAGNETIC materials, NANOPARTICLES, IRON compounds, PLATINUM compounds, FLUORESCEIN isothiocyanate |
| مستخلص: |
Recently, superparamagnetic chemically disordered face-centered cubic (fcc) FePt nanoparticles have been demonstrated as superior negative contrast agents for magnetic resonance imaging (MRI). However, their low intracellular labeling efficiency has limited the potential usage and the nanotoxicity of the particles requires attention. We have developed fluorescein isothiocyanate-incorporated silica-coated FePt (FePt@SiO2-FITC) nanoparticles that exhibited not only a significant T1 and T2 MR contrast abilities but also a fluorescent property without significant cytotoxicities. These results suggest that silica-coated superparamagnetic FePt nanoparticles are potential nanodevices for the combination of fluorescence and MRI contrast used for cancer diagnosis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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