التفاصيل البيبلوغرافية
| العنوان: |
Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice. |
| المؤلفون: |
Vidal-Infer, Antonio, Aguilar, Maria A., Mi¤arro, Jose, Rodr¡guez-Arias, Marta |
| المصدر: |
Behavioral & Brain Functions; 2012, Vol. 8 Issue 1, p32-43, 12p, 2 Charts, 4 Graphs |
| مصطلحات موضوعية: |
ECSTASY (Drug), CEREBRAL cortex, DRUG administration, LABORATORY mice, HIPPOCAMPUS (Brain) |
| مستخلص: |
Background: Heavy binge drinking is increasingly frequent among adolescents, and consumption of 3,4- methylenedioxymethamphetamine (MDMA) is often combined with ethanol (EtOH). The long-lasting effects of intermittent exposure to EtOH and MDMA during adolescence on learning and memory were evaluated in adult mice using the Hebb-Williams maze. Methods: Adolescent OF1 mice were exposed to EtOH (1.25 g/kg) on two consecutive days at 48-h intervals over a 14-day period (from PD 29 to 42). MDMA (10 or 20 mg/kg) was injected twice daily at 4-h intervals over two consecutive days, and this schedule was repeated six days later (PD 33, 34, 41 and 42), resulting in a total of eight injections. Animals were initiated in the Hebb-Williams maze on PND 64. The concentration of brain monoamines in the striatum and hippocampus was then measured. Results: At the doses employed, both EtOH and MDMA, administered alone or together, impaired learning in the Hebb-Williams maze, as treated animals required more time to reach the goal than their saline-treated counterparts. The groups treated during adolescence with EtOH, alone or plus MDMA, also presented longer latency scores and needed more trials to reach the acquisition criterion score. MDMA induced a decrease in striatal DA concentration, an effect that was augmented by the co-administration of EtOH. All the treatment groups displayed an imbalance in the interaction DA/serotonin. Conclusions: The present findings indicate that the developing brain is highly vulnerable to the damaging effects of EtOH and/or MDMA, since mice receiving these drugs in a binge pattern during adolescence exhibit impaired learning and memory in adulthood. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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