التفاصيل البيبلوغرافية
| العنوان: |
The Microalga Spirulina platensis Presents Anti-inflammatory Action as well as Hypoglycemic and Hypolipidemic Properties in Diabetic Rats. |
| المؤلفون: |
Joventino, Ivan P., Alves, Henrique G.R., Neves, Lia C., Pinheiro-Joventino, Francisca, Leal, Luzia Kalyne A.M., Neves, Samya A., Ferreira, Francisco Valdeci, Brito, Gerly Anne C., Viana, Glauce B. |
| المصدر: |
Journal of Complementary & Integrative Medicine; Jan2012, Vol. 9 Issue 1, p-1, 28p, 3 Color Photographs, 8 Graphs |
| مصطلحات موضوعية: |
ALGAE, ANALYSIS of variance, ANIMAL experimentation, ANTI-inflammatory agents, ANTILIPEMIC agents, BIOLOGICAL assay, DIABETES, HYPOGLYCEMIC agents, IMMUNOHISTOCHEMISTRY, LIPIDS, NEUTROPHILS, RATS, RESEARCH funding, STATISTICS, T-test (Statistics), TUMOR necrosis factors, DATA analysis, PRE-tests & post-tests, DESCRIPTIVE statistics, IN vitro studies |
| مستخلص: |
Spirulina platensis (Spi) is a microalga presenting high contents of proteins, ?-linolenic acid, vitamins and minerals, and showing many biological activities. It is a promising drug for the treatment of diseases including diabetes. The objectives of this work were to study Spi effects on alloxan-induced diabetic rats, and associate this to its anti-inflammatory activity. The treatment with Spi (25, 50 or 100 mg/kg, p.o.) started 48 h after the alloxan injection, continuing for 5 or 10 days. Biochemical parameters were measured in sera of treated and untreated animals. The anti-inflammatory activity of Spi was assessed by the formalin test and carrageenan-induced paw edema in mice. Immunostainings for TNF-alpha were carried out in the carrageenan-induced paw edema in rats, before and after the Spi treatment, and its effect on the release of myeloperoxidase from human neutrophils was also determined. Spi decreased glycemia as well as triglyceride and total cholesterol levels of diabetic rats. Levels of urea and creatinine were also reduced, while liver transaminases were unaltered. Spi also decreased dose-dependently the 1st (neurogenic) and mainly the 2nd phase (inflammatory) of the formalin test, as well as the carrageenan-induced paw edema in mice. The anti-inflammatory effect of Spi was further confirmed by decreases in TNF-alpha immunostaining in the inflamed paw and in the myeloperoxidase release from human neutrophils. The results showed that the anti-diabetic effect of S. platensis is already manifested after a 5-day treatment. Additionally, considering the relationship between diabetes and inflammation, the microalga anti-inflammatory action may also be involved. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Complementary & Integrative Medicine is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
