التفاصيل البيبلوغرافية
| العنوان: |
Diagnostic performance of F-fluorothymidine PET/CT for primary colorectal cancer and its lymph node metastasis: comparison with F-fluorodeoxyglucose PET/CT. |
| المؤلفون: |
Nakajo, Masatoyo, Nakajo, Masayuki, Kajiya, Yoriko, Jinguji, Megumi, Nishimata, Nobuaki, Shimaoka, Shunji, Nihara, Tohru, Aridome, Kuniaki, Tanaka, Sadao, Fukukura, Yoshihiko, Tani, Atushi, Koriyama, Chihaya |
| المصدر: |
European Journal of Nuclear Medicine & Molecular Imaging; Aug2013, Vol. 40 Issue 8, p1223-1232, 10p, 5 Diagrams, 5 Charts |
| مصطلحات موضوعية: |
THYMIDINE, DEOXYRIBONUCLEOSIDES, POSITRON emission tomography, RADIONUCLIDE imaging, TOMOGRAPHY |
| مستخلص: |
Purpose: To examine the diagnostic performance of F-fluorothymidine (FLT) PET/CT in primary and metastatic lymph node colorectal cancer foci in comparison with F-fluorodeoxyglucose (FDG) PET/CT. Methods: The study population comprised 28 patients with 30 newly diagnosed colorectal cancers who underwent surgical resection of the primary lesion and regional lymph nodes after both FLT and FDG PET/CT. The associations between SUVmax levels and pathological factors were evaluated using the Mann-Whitney U or Kruskal-Wallis test. Differences in diagnostic indexes for detecting nodal metastasis between the two tracers were estimated using the McNemar exact or χ test. Results: All 30 primary cancers (43.0 ± 20.0 mm, range 14 - 85 mm) were visualized by both tracers, but none of the FLT SUVmax values exceeded the FDG SUVmax values in any of the primary cancers (6.6 ± 2.4 vs. 13.6 ± 5.8, p < 0.001). The sensitivity, specificity and accuracy for detecting nodal metastasis were 41 % (15/37), 98.8 % (493/499) and 94.8 % (508/536) for FDG PET/CT, and 32 % (12/37), 98.8 % (493/499) and 94.2 % (505/536) for FLT PET/CT, respectively. The sensitivity ( p = 0.45), specificity ( p = 0.68) and accuracy ( p = 0.58) were not different between the tracers. Nodal uptake of FLT and FDG was discordant in 7 (19 %) of 37 metastatic nodes. There were ten concordant true-positive nodes of which six showed higher FDG SUVmax and four showed higher FLT SUVmax, but the difference between FDG and FLT SUVmax was not significant (5.56 ± 3.55 and 3.62 ± 1.45, respectively; p = 0.22). Conclusion: FLT has the same potential as FDG in PET/CT for the diagnosis of primary and nodal foci of colorectal cancer despite significantly lower FLT uptake in primary foci. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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