التفاصيل البيبلوغرافية
العنوان: |
Pharmacokinetics of Codeine After Single-and Multiple-Oral-Dose Administration to Normal Volunteers. |
المؤلفون: |
Guay, D. R. P., Awni, W. M., Halstenson, C. E., Findlay, J. W. A., Opsahl, J. A., Abraham, P. A., Jones, E. C., Matzke, Gary R. |
المصدر: |
Journal of Clinical Pharmacology; Dec1987, Vol. 27 Issue 12, p983-987, 5p |
مستخلص: |
The pharmacokinetics of codeine, codeine glucuronide, morphine, and morphine glucuronide were assessed after single-(60 mg) and multiple-dose (60 mg every six hours for nine doses) oral administration of codeine sulfate to six normal volunteers. Multiple blood and urine samples were collected after administration of the single- and last multiple-oral doses. Drug concentrations were analyzed using radioimmunoassay techniques. No significant alterations in codeine pharmacokinetics were noted after multiple-dose oral administration. However, accumulation of morphine during multiple dosing was significant (AUC24 = 102 ± 33 ng/mL/hr after single dose versus 212 ± 118 ng/mL/hr after the last multiple dose). Peak concentration and AUC24 data for morphine glucuronide indicated that significant accumulation of this compound occurs upon multiple-dose administration. These data indicate that morphine and morphine glucuronide serum concentrations are significantly increased during chronic oral codeine therapy and suggest that morphine, and perhaps morphine glucuronide, contribute significantly to the analgesic activity of chronic oral codeine therapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |