التفاصيل البيبلوغرافية
| العنوان: |
Human μ-Opioid Receptor Variation and Alcohol Dependence. |
| المؤلفون: |
Sander, Thomas, Gscheidel, Nicola, Wendel, Birgit, Samochowiec, Jerzy, Smolka, Michael, Rommelspacher, Hans, Schmidt, Lutz G., Hoehe, Margret R. |
| المصدر: |
Alcoholism: Clinical & Experimental Research; 1998, Vol. 22 Issue 9, p2108-2110, 3p |
| مستخلص: |
μ-Opioid receptor-mediated neurotransmission is involved in the reward, tolerance, and withdrawal effects of alcohol. The present association study tested the hypothesis that the common Asn40Asp substitution polymorphism in the N-terminal domain of the human fi-opioid receptor (OPRM)confers vulnerability to subtypes of alcohol dependence. The genotypes of the AsrvWAsp substitution polymorphism were assessed in 327 German alcohol-dependent subjects (according to ICD-10) and in 340 control subjects of German descent, using an assay based on allele-specific polymerase chain reaction. To select alcoholics with a presumed high genetic load, three subgroups were delineated, marked by (1) a family history of parental alcoholism ( n= 114); (2) the inability to abstain from alcohol before the age of 26 years (n = 73); and (3) a history of alcohol withdrawal seizure or delirium (n= 107). The frequency of the Asp40 allele did not differ significantly between the controls [f(Asp40) = 0.078] and either the entire group of alcoholics [f(Asp40) = 0.107; p= 0.066], or the alcoholics with parental alcoholism [f(Asp40) = 0.114; p= 0.094], or the early-onset alcoholics [f (Asp40) = 0.096; p= 0.471] or the alcoholics with severe withdrawal symptoms [f(Asp40) = 0.098; p= 0.350]. Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRMgene contributes a major effect to the pathogenesis of alcohol dependence. Key Words: Alcohol Dependence, OPRMfi-Opioid Receptor, Association, Genetics. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
