التفاصيل البيبلوغرافية
| العنوان: |
Lack of evidence of foetal microchimerism in female Spanish patients with systemic sclerosis. |
| المؤلفون: |
Selva-O'Callaghan, A, Mijares-Boeckh-Behrens, T, Prades, E Balada, Solans-Laqué, R, Simeón-Aznar, CP, Fonollosa-Pla, V, Vilardell-Tarrés, M |
| المصدر: |
Lupus; 2003, Vol. 12 Issue 1, p15-20, 6p |
| مصطلحات موضوعية: |
SCLERODERMA (Disease), AUTOIMMUNITY |
| مصطلحات جغرافية: |
SPAIN |
| مستخلص: |
Our objective was to study the presence of microchimerism in a series of 47 female Spanish patients with scleroderma (SSc) and to compare with a control group. Polymerase chain reaction was used to identify Y-chromosome sequences in DNA extracted from peripheral blood cells.Y-chromosome sequences were found in DNA from peripheral blood cells in four out of 47 (8.5%) patients with scleroderma (two limited and two diffuse) and in two out of 40 (5%) healthy women (no statistical differences were found). When we compared SSc patients and healthy controls who had had at least one male child, four out of 29 (13.7%) and two out of 26 (7.6%) had microchimerism respectively (no statistically significant differences were found). Patients with both scleroderma and persistent microchimerism had had a male offspring. Foetal microchimerism does not seem to play a major role in most cases of female Spanish patients with SSc. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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