التفاصيل البيبلوغرافية
| العنوان: |
In vitro differential modulation of immune response by probiotics in porcine peripheral blood mononuclear cells. |
| المؤلفون: |
Mata-Haro, Verónica, Reséndiz-Sandoval, Mónica, Hernández, Jesús |
| المصدر: |
Food & Agricultural Immunology; Jun2014, Vol. 25 Issue 2, p209-219, 11p |
| مصطلحات موضوعية: |
IMMUNE response, PROBIOTICS, CYTOKINES, T cells, BIFIDOBACTERIUM, ENTEROCOCCUS faecalis, LACTOBACILLUS reuteri |
| مستخلص: |
The purpose of this study was to evaluate the extent of cytokine induction and T cell proliferation in lactic acid bacteria (LAB)-stimulated porcine peripheral blood mononuclear cells (PBMCs). Porcine PBMCs were stimulated with phytohaemagglutinin (PHA) and then incubated withBifidobacterium angulatum,Enterococcus faecalisandLactobacillus reuteri. A decrease in the mRNA expression of interferon-gamma (IFN-γ) was detected; however, only a significant increase (P<0.05) in interleukin (IL)-10 expression was found in cells stimulated withE. faecalis. No changes in transforming growth factor-beta (TGF-β) were observed with neither of the probiotics tested nor in T cell proliferation between LAB-stimulated and control groups. These results suggest a possible immunomodulatory probiotic effect and this effect could be due to a decrease in the inflammatory T helper 1 (Th1) immune response, and an increase of T regulatory function, as suggested by the augmented expression of IL-10. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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