التفاصيل البيبلوغرافية
| العنوان: |
Application Of Markov Chain To The Pattern Of Mitochondrial Deoxyribonucleic Acid Mutations. |
| المؤلفون: |
Vantika, Sandy, Pasaribu, Udjianna S. |
| المصدر: |
AIP Conference Proceedings; 2014, Vol. 1589, p296-299, 4p |
| مصطلحات موضوعية: |
MITOCHONDRIAL DNA, MARKOV processes, GENETIC mutation, CYTOSINE, GUANINE nucleotide exchange factors, ADENINE nucleotides |
| مستخلص: |
This research explains how Markov chain used to model the pattern of deoxyribonucleic acid mutations in mitochondrial (mitochondrial DNA). First, sign test was used to see a pattern of nucleotide bases that will appear at one position after the position of mutated nucleotide base. Results obtained from the sign test showed that for most cases, there exist a pattern of mutation except in the mutation cases of adenine to cytosine, adenine to thymine, and cytosine to guanine. Markov chain analysis results on data of mutations that occur in mitochondrial DNA indicate that one and two positions after the position of mutated nucleotide bases tend to be occupied by particular nucleotide bases. From this analysis, it can be said that the adenine, cytosine, guanine and thymine will mutate if the nucelotide base at one and/or two positions after them is cytosine. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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