التفاصيل البيبلوغرافية
| العنوان: |
Chronic Corticosterone Exposure Persistently Elevates the Expression of Memory-Related Genes in the Lateral Amygdala and Enhances the Consolidation of a Pavlovian Fear Memory. |
| المؤلفون: |
Monsey, Melissa S., Boyle, Lara M., Zhang, Melinda L., Nguyen, Caroline P., Kronman, Hope G., Ota, Kristie T., Duman, Ronald S., Taylor, Jane R., Schafe, Glenn E. |
| المصدر: |
PLoS ONE; Mar2014, Vol. 9 Issue 3, p1-10, 10p |
| مصطلحات موضوعية: |
CORTICOSTERONE, AMYGDALOID body, FEAR, ANXIETY disorders, MEMORY, PSYCHOLOGICAL stress, COGNITIVE psychology |
| مستخلص: |
Chronic exposure to stress has been widely implicated in the development of anxiety disorders, yet relatively little is known about the long-term effects of chronic stress on amygdala-dependent memory formation. Here, we examined the effects of a history of chronic exposure to the stress-associated adrenal steroid corticosterone (CORT) on the consolidation of a fear memory and the expression of memory-related immediate early genes (IEGs) in the lateral nucleus of the amygdala (LA). Rats received chronic exposure to CORT (50 μg/ml) in their drinking water for 2 weeks and were then titrated off the CORT for an additional 6 days followed by a 2 week ‘wash-out’ period consisting of access to plain water. Rats were then either sacrificed to examine the expression of memory-related IEG expression in the LA or given auditory Pavlovian fear conditioning. We show that chronic exposure to CORT leads to a persistent elevation in the expression of the IEGs Arc/Arg3.1 and Egr-1 in the LA. Further, we show that rats with a history of chronic CORT exposure exhibit enhanced consolidation of a fear memory; short-term memory (STM) is not affected, while long-term memory (LTM) is significantly enhanced. Treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine following the chronic CORT exposure period was observed to effectively reverse both the persistent CORT-related increases in memory-related IEG expression in the LA and the CORT-related enhancement in fear memory consolidation. Our findings suggest that chronic exposure to CORT can regulate memory-related IEG expression and fear memory consolidation processes in the LA in a long-lasting manner and that treatment with fluoxetine can reverse these effects. [ABSTRACT FROM AUTHOR] |
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