التفاصيل البيبلوغرافية
| العنوان: |
The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. |
| المؤلفون: |
Remus, Ebony Washington, O'Donnell, Jr., Robert E., Rafferty, Kathryn, Weiss, Daiana, Joseph, Giji, Csiszar, Katalin, Fong, Sheri F. T., Taylor, W. Robert |
| المصدر: |
American Journal of Physiology: Heart & Circulatory Physiology; Oct2012 Part2, Vol. 303 Issue 8, pH1067-H1075, 9p |
| مستخلص: |
Abdominal aortic aneurysms (AAAs) are a major cause of morbidity and mortality in the United States today. We employed a model for AAA development using apolipoprotein E knock out mice fed a high-fat diet and treated with ANG II and β-aminopropionitrile (β-APN) for 4 wk. ANG II induces hypertension and atherosclerotic disease, whereas β-APN inhibits the activity of the lysyl oxidase/ lysyl oxidase-like protein (LOX/LOXL) family members. LOX/LOXL family members crosslink collagen and elastin in the extracellular matrix and therefore contribute to the integrity and stabilization of a healthy vessel wall. In this model, cotreatment with ANG II and β-APN caused a 90% AAA incidence and increased atherosclerotic lesion formation from less than 5% to greater than 25% after 4 wk. In more atheroprotected mouse strains (C57BL/6 and BalbC), cotreatment with ANG II and β-APN caused 50% and 40% AAA incidence, respectively. These data demonstrate the importance of LOX/LOXL to the stability of the vessel wall. Therapeutic strategies to overexpress LOX/LOXL enzymes or to support the crosslinking of soluble matrix proteins in a polymeric scaffold are a promising opportunity to achieve stabilization of AAAs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
