التفاصيل البيبلوغرافية
| العنوان: |
Effect of 20-hydroxyeicosatetraenoic acid on biological behavior of human villous trophoblasts and uterine vascular smooth muscle cells. |
| المؤلفون: |
SHUAIJUN LU, CHANGLING ZHU, ANXIONG LONG, LONGYI TAN, QIAN LI, YULI ZHU |
| المصدر: |
Molecular Medicine Reports; 2014, Vol. 9 Issue 5, p1889-1894, 6p |
| مصطلحات موضوعية: |
HYDROXYEICOSATETRAENOIC acid, TROPHOBLAST, MUSCLE cells, CELL migration, APOPTOSIS |
| مستخلص: |
Abstract. During pregnancy, disorders in uterine spiral artery remodeling (USAR) cause preeclampsia and other diseases. The aim of this study was to investigate the effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on the biological behavior of human villous trophoblasts (HVTs) and human uterine vascular smooth muscle cells (HUVSMCs), and explore the role of 20-HETE in USAR. 20-HETE and its inhibitor HET0016 were used to study migration, invasion and apoptosis in the HVT and HVT-HUVSMC models. 20-HETE inhibited the migration and invasion of HVTs, and inhibited apoptosis in HUVSMCs and HUVSMCs co-cultured with HVTs. 20-HETE had thus obvious effects on the biological behavior of HVTs and HUVSMCs. These effects may cause USAR disorders and vascular dysfunction, leading to preeclampsia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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