التفاصيل البيبلوغرافية
| العنوان: |
Hypertension is associated with serologically active disease in patients with systemic lupus erythematosus: role of increased Th1/Th2 ratio and oxidative stress. |
| المؤلفون: |
Lozovoy, MAB, Simão, ANC, Morimoto, HK, Iryioda, TMV, Panis, C, Reiche, EMV, Borelli, SD, Oliveira, SR, Cecchini, R, Dichi, I |
| المصدر: |
Scandinavian Journal of Rheumatology; 2014, Vol. 43 Issue 1, p59-62, 4p |
| مصطلحات موضوعية: |
SYSTEMIC lupus erythematosus, HYPERTENSION, SEROLOGY, OXIDATIVE stress, T helper cells, KIDNEY physiology |
| مستخلص: |
Objectives: To determine whether disease activity verified by laboratorial parameters is associated with a higher frequency of hypertension in patients with systemic lupus erythematosus (SLE) without renal impairment and to investigate factors that could influence this hypertension. Method: This study included 102 controls, 70 patients with inactive SLE, and 53 patients with active SLE without renal impairment. We evaluated T helper type 1 (Th1)/Th2 lineage cytokines, nitric oxide (NO), insulin resistance (IR), and oxidative stress. Results: Patients with active SLE had a higher probability of developing hypertension compared to controls [odds ratio (OR) 3.833, 95% confidence interval (CI) 1.806-8.137, p < 0.0003] and patients with inactive SLE (OR 2.215, 95% CI 1.032-4.752, p = 0.0394). Active SLE patients had a higher interleukin (IL)-12/IL-4 ratio (p < 0.05) than both controls and inactive SLE patients. Protein oxidation was significantly higher in patients with active SLE than in the control group and in patients with inactive SLE (p < 0.01 and p < 0.05, respectively). Multivariate analysis revealed an association between the presence of hypertension and he levels of glucose (p = 0.0276), insulin (p = 0.0498), hydroperoxides (p = 0.0221), IFN-γ (p = 0.0494), IL-17 (p = 0.0272), IL-12/IL-10 (p = 0.0373), IFN-γ/IL-10 (p = 0.0142), IFN-γ/IL-4 (p = 0.0320), and adiponectin (p = 0.0433). Conclusions: Patients with active SLE without renal impairment had an increased frequency of high blood pressure (43.4%) compared with patients with inactive SLE (25.7%) and controls (16.7%). Hypertension was associated with serologically active disease and was influenced by an increased Th1/Th2 ratio and oxidative stress. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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